abstract：:Pheochromocytomas (PCCs) and paragangliomas (PGLs) are rare neuroendocrine tumors of the adrenal glands and the sympathetic and parasympathetic paraganglia. They can occur sporadically or as a part of different hereditary tumor syndromes. About 30% of PCCs and PGLs are currently believed to be caused by germline mutat...

journal_title：Endocrine-related cancer

authors： Welander J,Söderkvist P,Gimm O

更新日期：2011-12-01 00:00:00

abstract：:Epidemiologic and experimental evidence suggest that a subset of breast cancer is insulin responsive, but it is unclear whether safe and effective therapies that target the insulin receptor (IR), which is homologous to oncogenes of the tyrosine kinase class, can be developed. We demonstrate that both pharmacologic inh...

journal_title：Endocrine-related cancer

authors： Dool CJ,Mashhedi H,Zakikhani M,David S,Zhao Y,Birman E,Carboni JM,Gottardis M,Blouin MJ,Pollak M

更新日期：2011-11-14 00:00:00

abstract：:Resistance to anoikis (matrix deprivation-induced apoptosis) is a critical component of the metastatic cascade. Molecular mechanisms underlying resistance to anoikis have not been reported in thyroid cancer cells. For an in vitro model of anoikis, we cultured follicular, papillary, and anaplastic thyroid cancer cell l...

journal_title：Endocrine-related cancer

authors： Jensen K,Patel A,Klubo-Gwiezdzinska J,Bauer A,Vasko V

更新日期：2011-09-20 00:00:00

abstract：:The androgen receptor (AR) is well known to play a central role in the pathogenesis of prostate cancer (PCa). In several studies, AR was overexpressed in castration-resistant PCa (CRPC). However, the mechanism of AR overexpression in CRPC is not fully elucidated. Y-box binding protein-1 (YB-1) is a pleiotropic transcr...

journal_title：Endocrine-related cancer

authors： Shiota M,Takeuchi A,Song Y,Yokomizo A,Kashiwagi E,Uchiumi T,Kuroiwa K,Tatsugami K,Fujimoto N,Oda Y,Naito S

更新日期：2011-07-11 00:00:00

abstract：:Obesity increases both the risk and mortality associated with many types of cancer including that of the breast. In mice, obesity increases both incidence of spontaneous tumors and burden of transplanted tumors. Our findings identify leptin, an adipose secreted cytokine, in promoting increased mammary tumor burden in ...

journal_title：Endocrine-related cancer

authors： Zheng Q,Dunlap SM,Zhu J,Downs-Kelly E,Rich J,Hursting SD,Berger NA,Reizes O

更新日期：2011-07-11 00:00:00

abstract：:Chemotherapy remains the major treatment option for castration-resistant prostate cancer (CRPC) and limited cytotoxic options are available. Inherent chemotherapy resistance occurs in half of all patients and inevitably develops even in those who initially respond. Docetaxel has been the mainstay of therapy for 6 year...

journal_title：Endocrine-related cancer

authors： Mahon KL,Henshall SM,Sutherland RL,Horvath LG

更新日期：2011-07-04 00:00:00

abstract：:Tumor-induced osteomalacia (TIO) is a rare and fascinating paraneoplastic syndrome in which patients present with bone pain, fractures, and muscle weakness. The cause is high blood levels of the recently identified phosphate and vitamin D-regulating hormone, fibroblast growth factor 23 (FGF23). In TIO, FGF23 is secret...

journal_title：Endocrine-related cancer

authors： Chong WH,Molinolo AA,Chen CC,Collins MT

更新日期：2011-06-08 00:00:00

abstract：:Mutations of the aryl hydrocarbon receptor interacting protein (AIP) gene are associated with pituitary adenomas that usually occur as familial isolated pituitary adenomas (FIPA). Detailed pathological and tumor genetic data on AIP mutation-related pituitary adenomas are not sufficient. Non-identical twin females pres...

journal_title：Endocrine-related cancer

authors： Villa C,Lagonigro MS,Magri F,Koziak M,Jaffrain-Rea ML,Brauner R,Bouligand J,Junier MP,Di Rocco F,Sainte-Rose C,Beckers A,Roux FX,Daly AF,Chiovato L

更新日期：2011-06-08 00:00:00

abstract：:Paragangliomas (PGLs) have widely different metastastic potentials. Two different types of PGLs can be defined by expression profiling. Cluster 1 PGLs exhibit VHL and/or succinate dehydrogenase (SDH) mutations and a pseudohypoxic phenotype. RET and neurofibromatosis type 1 (NF1) mutations occur in cluster 2 tumors cha...

journal_title：Endocrine-related cancer

authors： Span PN,Rao JU,Oude Ophuis SB,Lenders JW,Sweep FC,Wesseling P,Kusters B,van Nederveen FH,de Krijger RR,Hermus AR,Timmers HJ

更新日期：2011-04-28 00:00:00

abstract：:Although targeted therapy, including inhibitors of mammalian target of rapamycin (mTOR) and vascular endothelial growth factor, being developed for carcinoids arised from the gastrointestinal tract, treatment for locally advanced or metastatic bronchial carcinoids (BCs) remains lacking. Traditional cytotoxic chemother...

journal_title：Endocrine-related cancer

authors： Dong M,Yao JC

更新日期：2011-04-28 00:00:00

abstract：:Elevated expression of steroid receptor coactivator-3 (SRC-3), a member of the p160 family of nuclear receptor coactivators, has been implicated in tamoxifen resistance of breast tumors while the involvement of the two other members of this family, SRC-1 and SRC-2, is less well characterized. In this study, using smal...

journal_title：Endocrine-related cancer

authors： Karmakar S,Foster EA,Blackmore JK,Smith CL

更新日期：2010-12-21 00:00:00

abstract：:Ovarian cancer remains one of the leading causes of cancer deaths. Thus, new biomarkers predictive of response to the standard paclitaxel-carboplatin treatment are needed to improve chemotherapy strategies. MicroRNAs have the potential to modify drug outcomes. Based on this, we have demonstrated in this study that pat...

journal_title：Endocrine-related cancer

authors： Leskelä S,Leandro-García LJ,Mendiola M,Barriuso J,Inglada-Pérez L,Muñoz I,Martínez-Delgado B,Redondo A,de Santiago J,Robledo M,Hardisson D,Rodríguez-Antona C

更新日期：2010-12-21 00:00:00

abstract：:The prognosis remains ill-defined in patients with liver metastases of well-differentiated (WD) digestive endocrine carcinomas (DEC) with high Ki-67 index. The objectives of this study were to determine whether Ki-67 index, tumor differentiation, and extent of liver involvement are independent prognostic factors in pa...

journal_title：Endocrine-related cancer

authors： Hentic O,Couvelard A,Rebours V,Zappa M,Dokmak S,Hammel P,Maire F,O'Toole D,Lévy P,Sauvanet A,Ruszniewski P

更新日期：2010-12-13 00:00:00

abstract：:Ovarian epithelial cancer is the leading cause of death among gynecological malignancies. FSH may increase the risk of ovarian malignancy and play an important role in ovarian carcinogenesis. Our previous studies showed that FSH increases the expression of VEGF through survivin. In this study, the function and mechani...

journal_title：Endocrine-related cancer

authors： Huang Y,Jin H,Liu Y,Zhou J,Ding J,Cheng KW,Yu Y,Feng Y

更新日期：2010-11-30 00:00:00

abstract：:The molecular pathways leading to thyroid follicular neoplasia are incompletely understood, and the diagnosis of follicular tumors is a clinical challenge. To provide leads to the pathogenesis and diagnosis of the tumors, we examined the global transcriptome signatures of follicular thyroid carcinoma (FC) and normofol...

journal_title：Endocrine-related cancer

authors： Borup R,Rossing M,Henao R,Yamamoto Y,Krogdahl A,Godballe C,Winther O,Kiss K,Christensen L,Høgdall E,Bennedbaek F,Nielsen FC

更新日期：2010-07-28 00:00:00

abstract：:Pheochromocytomas are catecholamine-producing tumors which are generally benign, but which can also present as or develop into malignancy. Molecular pathways of malignant transformation remain poorly understood. Pheochromocytomas express various trophic peptides which may influence tumoral cell behavior. Here, we inve...

journal_title：Endocrine-related cancer

authors： Thouënnon E,Pierre A,Tanguy Y,Guillemot J,Manecka DL,Guérin M,Ouafik L,Muresan M,Klein M,Bertherat J,Lefebvre H,Plouin PF,Yon L,Anouar Y

更新日期：2010-06-25 00:00:00

abstract：:Endocrine disturbances are among the most frequently reported complications in childhood cancer survivors, affecting between 20 and 50% of individuals who survive into adulthood. Most endocrine complications are the result of prior cancer treatments, especially radiotherapy. The objective of the present review is to d...

journal_title：Endocrine-related cancer

authors： Chemaitilly W,Sklar CA

更新日期：2010-06-03 00:00:00

abstract：:Our main objective was to search for mutations in candidate genes and for paired box gene 8-peroxisome proliferator-activated receptor gamma (PAX8-PPARgamma) rearrangement in a well-differentiated angioinvasive follicular thyroid carcinoma (FTC) causing hyperthyroidism. DNA and RNA were extracted from the patient's th...

journal_title：Endocrine-related cancer

authors： Lado-Abeal J,Celestino R,Bravo SB,Garcia-Rendueles ME,de la Calzada J,Castro I,Castro P,Espadinha C,Palos F,Soares P,Alvarez CV,Sobrinho-Simões M,Cameselle-Teijeiro J

更新日期：2010-06-03 00:00:00

abstract：:There are currently few successful therapies for castration-resistant prostate cancer (CRPC). CRPC is thought to result from augmented activation of the androgen/androgen receptor (AR) signaling pathway, which could be enhanced by AR cofactors. In this study, heterochromatin protein 1beta (HP1beta), but not HP1alpha o...

journal_title：Endocrine-related cancer

authors： Shiota M,Song Y,Yokomizo A,Tada Y,Kuroiwa K,Eto M,Oda Y,Inokuchi J,Uchiumi T,Fujimoto N,Seki N,Naito S

更新日期：2010-05-18 00:00:00

abstract：:Parathyroid carcinoma (PaC) is a rare cause of primary hyperparathyroidism. Though the loss of the oncosuppressor CDC73/HRPT2 gene product, parafibromin, has been involved in the hyperparathyroidism-jaw tumor syndrome and in a consistent set of sporadic PaCs, parathyroid carcinogenesis remains obscure. MicroRNAs are a...

journal_title：Endocrine-related cancer

authors： Corbetta S,Vaira V,Guarnieri V,Scillitani A,Eller-Vainicher C,Ferrero S,Vicentini L,Chiodini I,Bisceglia M,Beck-Peccoz P,Bosari S,Spada A

更新日期：2010-02-18 00:00:00

abstract：:Several lines of evidence indicate that tumorigenesis is a complex multistep process, and that most, if not all, cancers acquire the same set of functional capabilities during development and progression, albeit through various mechanistic strategies. Increasing data show an important role of microRNAs (miRNAs or miRs...

journal_title：Endocrine-related cancer

authors： Santarpia L,Nicoloso M,Calin GA

更新日期：2010-01-29 00:00:00

abstract：:Therapeutic options for patients with metastatic medullary thyroid carcinoma (MTC) are limited due to lack of effective treatments. Thus, there is a need to thoroughly characterize the pathways of molecular pathogenesis and to identify potential targets for therapy in MTC. Since epidermal growth factor receptor (EGFR)...

journal_title：Endocrine-related cancer

authors： Rodríguez-Antona C,Pallares J,Montero-Conde C,Inglada-Pérez L,Castelblanco E,Landa I,Leskelä S,Leandro-García LJ,López-Jiménez E,Letón R,Cascón A,Lerma E,Martin MC,Carralero MC,Mauricio D,Cigudosa JC,Matias-Guiu X,Roble

更新日期：2010-01-29 00:00:00

abstract：:The aim of this randomized multicenter phase III trial was to compare chemotherapy and interferon (IFN) in patients with metastatic carcinoid tumors. Patients with documented progressive, unresectable, metastatic carcinoid tumors were randomized between 5-fluorouracil plus streptozotocin (day 1-5) and recombinant IFN-...

journal_title：Endocrine-related cancer

authors： Dahan L,Bonnetain F,Rougier P,Raoul JL,Gamelin E,Etienne PL,Cadiot G,Mitry E,Smith D,Cvitkovic F,Coudert B,Ricard F,Bedenne L,Seitz JF,Fédération Francophone de Cancérologie Digestive (FFCD).,Digestive Tumors Group of the F

更新日期：2009-12-01 00:00:00

abstract：:Oestrogen receptors (ESRs) regulate the growth and differentiation of normal ovarian epithelia. However, to date their role as biomarkers in the clinical setting of ovarian cancer remains unclear. In view of potential endocrine treatment options, we tested the role of ESR1 mRNA expression in ovarian cancer in the cont...

journal_title：Endocrine-related cancer

authors： Zamagni C,Wirtz RM,De Iaco P,Rosati M,Veltrup E,Rosati F,Capizzi E,Cacciari N,Alboni C,Bernardi A,Massari F,Quercia S,D'Errico Grigioni A,Dietel M,Sehouli J,Denkert C,Martoni AA

更新日期：2009-12-01 00:00:00

abstract：:Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized in man by parathyroid, pancreatic, pituitary and adrenal tumours. The MEN1 gene encodes a 610-amino acid protein (menin) which is a tumour suppressor. To investigate the in vivo role of menin, we developed a mouse model, by dele...

journal_title：Endocrine-related cancer

authors： Harding B,Lemos MC,Reed AA,Walls GV,Jeyabalan J,Bowl MR,Tateossian H,Sullivan N,Hough T,Fraser WD,Ansorge O,Cheeseman MT,Thakker RV

更新日期：2009-12-01 00:00:00

abstract：:The imprinted gene, neuronatin (NNAT), is one of the most abundant transcripts in the pituitary and is thought to be involved in the development and maturation of this gland. In a recent whole-genome approach, exploiting a pituitary tumour cell line, we identified hypermethylation associated loss of NNAT. In this repo...

journal_title：Endocrine-related cancer

authors： Revill K,Dudley KJ,Clayton RN,McNicol AM,Farrell WE

更新日期：2009-06-01 00:00:00

abstract：:Obestatin was identified as a gut peptide encoded by the ghrelin gene that interacts with the G protein-coupled receptor, GPR39. In this work, a sequential analysis of its transmembrane signalling pathway has been undertaken to characterize the intracellular mechanisms responsible for Akt activation. The results show ...

journal_title：Endocrine-related cancer

authors： Alvarez CJ,Lodeiro M,Theodoropoulou M,Camiña JP,Casanueva FF,Pazos Y

更新日期：2009-06-01 00:00:00

abstract：:Endometrial cancer is the most common gynecological malignancy in developed countries and represents the eighth leading cause of cancer related death in women. The growing incidence of endometrial cancer leads scientists and oncologists to identify effective preventive measures and also molecular markers for diagnosis...

journal_title：Endocrine-related cancer

authors： Chaudhry P,Asselin E

更新日期：2009-06-01 00:00:00

abstract：:Insulin-like growth factors (IGFs) are thought to promote tumour progression and metastasis in part by stimulating cell migration. Insulin receptor substrate-1 (IRS-1) and IRS-2 are multisite docking proteins positioned immediately downstream from the type I IGF and insulin receptors. IRS-2 but not IRS-1 has been repo...

journal_title：Endocrine-related cancer

authors： de Blaquière GE,May FE,Westley BR

更新日期：2009-06-01 00:00:00

abstract：:Tyrosine phosphorylation plays a critical role in growth regulation, and its aberrant regulation can be involved in carcinogenesis. The association of Shc (Src homolog and collagen homolog) adaptor protein family members in tyrosine phosphorylation signaling pathway is well recognized. Shc adaptor proteins transmit ac...

journal_title：Endocrine-related cancer

authors： Alam SM,Rajendran M,Ouyang S,Veeramani S,Zhang L,Lin MF

更新日期：2009-03-01 00:00:00

abstract：:'Calcitonin screening' is not accepted as the standard of care in daily practice. The clinical and surgical consequences of 'calcitonin screening' in a series of patients with mildly elevated basal calcitonin and pentagastrin stimulated calcitonin levels are presented. 260 patients with elevated basal (>10 pg/ml) and ...

journal_title：Endocrine-related cancer

authors： Scheuba C,Kaserer K,Moritz A,Drosten R,Vierhapper H,Bieglmayer C,Haas OA,Niederle B

更新日期：2009-03-01 00:00:00

abstract：:Neuroendocrine tumours (NET) of the gastroenteropancreatic system comprise a malignant entity with a low incidence. Only limited information is available on long-term clinical outcome and clinically applicable prognostic factors. We performed a retrospective analysis of a large, well-characterized centre-based patient...

journal_title：Endocrine-related cancer

authors： Pape UF,Berndt U,Müller-Nordhorn J,Böhmig M,Roll S,Koch M,Willich SN,Wiedenmann B

更新日期：2008-12-01 00:00:00

abstract：:Endocrine therapy has become the most important treatment option for women with estrogen receptor (ER)-positive breast cancer. Urgently needed are prognostic assays that can identify those who need additional adjuvant therapy, such as signal transduction inhibitors or chemotherapy, for ER-positive early breast cancer....

journal_title：Endocrine-related cancer

authors： Yamashita H,Nishio M,Toyama T,Sugiura H,Kondo N,Kobayashi S,Fujii Y,Iwase H

更新日期：2008-09-01 00:00:00

abstract：:Numerous epidemiological observations point to sex differences in lung cancer etiology and progression. The present study was aimed at understanding the bases of these sex differences. To test the effect of estradiol on tumor progression, we used a mouse model based on conditional Kras expression and concurrent deleti...

journal_title：Endocrine-related cancer

authors： Hammoud Z,Tan B,Badve S,Bigsby RM

更新日期：2008-06-01 00:00:00

abstract：:Novel strategies are needed for the treatment of adrenocortical tumors that are usually resistant to chemotherapy. Hecate, a 23-amino acid lytic peptide, was conjugated to the 15-amino acid (81-95) fragment of the human chorionic gonadotropin beta (CGbeta) chain, which would selectively kill cancer cells expressing th...

journal_title：Endocrine-related cancer

authors： Vuorenoja S,Rivero-Müller A,Ziecik AJ,Huhtaniemi I,Toppari J,Rahman NA

更新日期：2008-06-01 00:00:00

abstract：:It is well known that sex steroids play important roles in the development of invasive ductal carcinoma (IDC) of the human breast. However, biological significance of sex steroids remains largely unclear in ductal carcinoma in situ (DCIS), regarded as a precursor lesion of IDC, which is partly due to the fact that the...

journal_title：Endocrine-related cancer

authors： Shibuya R,Suzuki T,Miki Y,Yoshida K,Moriya T,Ono K,Akahira J,Ishida T,Hirakawa H,Evans DB,Sasano H

更新日期：2008-03-01 00:00:00

abstract：:Somatostatin-producing neuroendocrine tumors (SOM-NETs) of the duodenum and pancreas appear to be heterogeneous. To determine their clinicopathological profiles, respective data were analyzed on a series of 82 duodenal and 541 pancreatic NETs. In addition, the clinical records of 821 patients with duodenal or pancreat...

journal_title：Endocrine-related cancer

authors： Garbrecht N,Anlauf M,Schmitt A,Henopp T,Sipos B,Raffel A,Eisenberger CF,Knoefel WT,Pavel M,Fottner C,Musholt TJ,Rinke A,Arnold R,Berndt U,Plöckinger U,Wiedenmann B,Moch H,Heitz PU,Komminoth P,Perren A,Klöppel G

更新日期：2008-03-01 00:00:00

abstract：:To analyze the genetic alterations of pheochromocytomas and evaluate the difference among malignant, extra-adrenal, and benign pheochromocytomas. Forty-three tumor samples were tested for genetic changes using multiplex ligation-dependent probe amplification. Among them, 39 samples were available for protein expressio...

journal_title：Endocrine-related cancer

authors： Yuan W,Wang W,Cui B,Su T,Ge Y,Jiang L,Zhou W,Ning G

更新日期：2008-03-01 00:00:00

abstract：:This review focuses on the tumour types and symptoms associated with non-islet cell tumour-induced hypoglycaemia (NICTH) as well as the pathogenesis, diagnosis and treatment of this rare paraneoplastic phenomenon. In addition, we report two illustrative cases of patients suffering from NICTH caused by a solid fibrous ...

journal_title：Endocrine-related cancer

authors： de Groot JW,Rikhof B,van Doorn J,Bilo HJ,Alleman MA,Honkoop AH,van der Graaf WT

更新日期：2007-12-01 00:00:00

abstract：:Ten to fifteen percent of fine-needle aspiration biopsy (FNAB) of thyroid nodules are indeterminate. Galectin-3 (Gal-3) and the oncogene BRAFV600E are markers of malignancy useful to improve FNAB accuracy. The objective of this study was to determine whether the combined analysis of Gal-3 and BRAFV600E expression in t...

journal_title：Endocrine-related cancer

authors： Sapio MR,Guerra A,Posca D,Limone PP,Deandrea M,Motta M,Troncone G,Caleo A,Vallefuoco P,Rossi G,Fenzi G,Vitale M

更新日期：2007-12-01 00:00:00